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KMID : 0604520050310020161
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Journal of the Society of Cosmetic Scientists of Korea
2005 Volume.31 No. 2 p.161 ~ p.167
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Effect on Inhibition of Matrix Metalloproteinase-1 in Human Dermal Fibroblasts by Production of Exopolysaccharide from Mycelial Culture of Grifola frondosa
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Sim Gwan-Sub
Bae Joon-Tae
Lee Dong-Hwan
Kim Jin-Hwa
Lee Beom-Cheon
Pyo Hyeong-Bae
Choe Tae-Boo
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Abstract
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We investigated the effect on inhibition of matrix metalloproteinase (MMP) in human dermal fibroblast (HDF) by production of exopolysaccharide (GF-glucan) from mycelial culture of Grifola frondosa HB0071. The photoprotective potential of GF-glucan was tested in HDF exposed to ultraviolet-A (UVA) light. It was revealed that GF-glucan had an inhibitory effect on MMP-1 expression in UVA-irradiated HDF without any significant cytotoxicity. The treatment of UVA-irradiated HDF with GF-glucan resulted in a dose-dependent degrease in the expression level of MMP-1 protein and mRNA (by maximum 54.4% at an 0.5% GF-glucan). These results suggest that GF-glucan obtained from mycelial culture of G. frondosa HB0071 may contribute to inhibitory action in photoaging by reducing the MMP-1 related matrix degradation system.
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KEYWORD
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Grifola frondosa, exopolysacchrides, matrix metalioproteinase, skin aging, human dermal fibroblast
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